導語：如何才能寫好一篇英語感謝信，這就需要搜集整理更多的資料和文獻，歡迎閱讀由公務員之家整理的十篇范文，供你借鑒。

篇1

感謝父母的英語感謝信范文一Parents,

Dear Mom and Dad, thank you for the upbringing of my ex. In my life on the road, you have given me in every possible way of an enhanced level of care and concern! I will take away my life on the road, I will repay you well! Thank you again! I love you!

Your Baby

感謝父母的英語感謝信范文二My dearest Mummy and Daddy,

Thank you very much for what you had given me, taught me,arranged for me,prepared for me,and those you had done on my behalf which I might have most probably forgotten or misunderstood in the past. I really would like to repay you with my whole soul and ability. I could not wait any longer to say to you, You are my sunshine,forever!

Take care,every moment,every step,every second!

Your kid.

感謝父母的英語感謝信范文三My dearest Mummy and Daddy,

What does family mean? It means Father And Mother, I Love You.

Thank you, father. For you broke the habit of smoking when mother was pregnant. You began to smoke when you was thirteen. But you gave up it for the health of mother and I.

Thank you, mother. Thank you for bearing the sharp pain of childbirth. Thank you for not only giving me food, clothes and a place to live but also educating me honest, confidence and love.

Maybe I wont be very rich in the future, but I will try my best to be a good person to pay back your love.

Thank you!

篇2

dear mr li,

i’m very excited to write to express my thanks to you. i am now a freshman of wuhan university, which i have been dreaming about. mr li, i still remember the days when you taught me english. my english has been improved greatly because of your creative work. however, at one time, the pressure of examinations, too much homework and the high expectations made me depressed. i was tired of the warning that if i didn’t do my best, i wouldn’t have the chance to go to college. thanks for your encouragement; if not, i wouldn’t have realized my dream. and now i really understand you. i wish more and more of your students could go to their ideal colleges. are you still so busy? how i miss you!

hoping to hear from you soon.

yours,

li hua

篇3

Dear Mr. xxx,

Thank you so much for meeting with me yesterday at xxxxx. I really enjoyed discussing the mechanical engineering internship (#254987) posted for this coming summer and learning more about Allied Aircraft. I believe that my skills and abilities mesh well with the requirements for the position.

As I mentioned during the interview, I am currently a junior in the mechanical engineering program here at Penn State. Through my course work, I have gained experience in project management, teamwork, and leadership. Additionally, my previous work experience as a shift manager at McDonalds has given me practical experience in utilizing problem-solving techniques and teambuilding skillsboth important qualities as indicated in the description of the internship position at Allied Aircraft.

I want to reiterate my strong interest in the position. Please feel free to contact me at xxx-xxx-xxxXif I can provide you with any additional information.

Again, thank you for the opportunity to interview with you and for your consideration. Please extend my appreciation to the rest of the interview team as well.

Sincerely,

xxx

英語面試感謝信范文二

Thank You For Interview II

Dear (Bosss Name),

Thank you so much for seeing me yesterday. The interview confirmed what others have told me -that (Company Name) would be a terrific place for someone with my skills and interests.

I am convinced that I could make an impact and add value as a (job title) in your department.

As we reviewed my background, I hope that you came to a similar conclusion. It was indeed a pleasure to discuss the opportunities with you. I thank you again for the opportunity and look forward to our next interaction.

Again, you can reach me (when) (Call time) at (telephone), or you may leave a message on my answering machine, and I will return your call promptly.

Sincerely,

(Signature)

英語面試感謝信范文三

Dear (Bosss Name),

Thank you so much for seeing me yesterday. The interview confirmed what others have told me - that (Company Name) would be a terrific place for someone with my skills and interests.

I am convinced that I could make an impact and add value as a (job title) in your department. As we reviewed my background, I hope that you came to a similar conclusion. It was indeed a pleasure to discuss the opportunities with you. I thank you again for the opportunity and look forward to our next interaction.

Again, you can reach me (when) (Call time) at (telephone), or you may leave a message on my answering machine, and I will return your call promptly.

篇4

有關于寫給老師的英文感謝信范本1Dear Mr Li,

Im very excited to write to express my thanks to you. I am now a freshman of Wuhan University, which I have been dreaming about. Mr Li, I still remember the days when you taught me English.

My English has been improved greatly because of your creative work. However, at one time, the pressure of examinations, too much homework and the high expectations made me depressed. I was tired of the warning that if I didnt do my best, I wouldnt have the chance to go to college. Thanks for your encouragement; if not, I wouldnt have realized my dream. And now I really understand you.

I wish more and more of your students could go to their ideal colleges. Are you still so busy? How I miss you!

Hoping to hear from you soon.

Yours,

Li Hua

有關于寫給老師的英文感謝信范本2Dear teacher ,

I am writing to you to express my thanks for your help in learning English and speaking English.

During these days in your class, I have learned much from you and it is very helpful to me. Firstly, you let me know what is the west thinking pattern—straight thinking pattern. And, I think, it is very important to understand the west’s thoughts. As you know, this can help me with my examination and interaction with foreigners. Secondly, I have got enough confidence in speaking in English from your class and it took me a long time to gain this confidence.

Now, I always express my ideas in English as possible as I can. It’s great to do that. The last not the least, I find that learning English is not an boring thing as before and I’m interested in studying English which was just a necessary task to pass examinations. Reading, listening or speaking all become interesting and I really enjoy it.

Above all, I want to say thanks again to you. And thank you for your time.

Good luck

有關于寫給老師的英文感謝信范本3Dear Teacher:

This is a special day, we have presented a bouquet of flowers, gifts to the world of your peaches and plums, spectrum a Ode to Joy, for your eyes flicker disperse tired, for you loosen the amount of wrinkled patterns.

The singing is to thank: the teacher, thank you! Thank you do not make learning to become crafts, but have become a kind of joy; Thank you for letting me know their value; Thank you for helping me find their expertise, but let me do things better; Thank you for being one I can never trust people - will be in trouble in their lives to help people.

The singing is a blessing: teacher, happy holidays! Insatiable in learning, be tireless in teaching, peaches and plums fragrance, their music is happy and harmonious. I wish you a happy holiday! Not only in the Teacher's Day today, there is a tomorrow, the day after tomorrow, Tai Houtian, I wish your life every day, every minutes, every second, the surface is always the same smile.

The singing is concerned about: the teacher, you worked hard! Your use of sweat, nurturing the tender shoots of spring have just ground-breaking. Your care is like the genial spring, warm our hearts and minds. Let us protect your healthy growth, formed in the autumn fruit.

篇5

大三下學期，我開始忙于在校外的實習，英語又被晾在了一邊。事實上，當時我產生了破罐子破摔的心理。我想，反正人又不是靠英語活著呢，考不上就考不上唄，憑著自己其他方面的能力總能養(yǎng)活自己的。可想而知，我以40來分的成績結束了第三次征程。說實話，我浪費的不僅是這三次機會，更重要的是花在英語學習上的時間以及被英語所籠罩的心理陰影。試想一下，假如我珍惜機會，努力學習的話，也許我第一次或者第二次就會過關的。這樣我就可以把大把的時間用在其他方面上。不幸的是，我一次又一次的浪費機會，換來的只是惡性循環(huán)。

大四的情況不同了，因為我要面對更嚴峻的工作問題。以前，家里對我基本上是放任自流的，很少過問我學習上的事情。這次，哥哥逼著我要耐下心來學好英語。因為他感到如果我英語不過關的話，畢業(yè)時就不是學士學位，戶口也不能落在深圳或廣州等大城市。為此，他甚至要求我把英語以外的事情都放下來，專心學習英語。 這樣，我被分在了暑期班上。在學習中，與我年齡相差無幾的老師們的細致、活波的授課對我?guī)椭醮?。經過在暑期四級強化班的系統(tǒng)學習，我在英語學習方法和技能上都有很大的提高。這一點在我做歷年四級真題和?？碱}上就明顯的顯示了出來。

老師們負責耐心細致的講解對我尤其幫助最大。你們不僅在課上為我們細致講解有關問題，下課后從不早早走出教室，而是耐心地等待我們問問題，直到沒有人問你們問題后才離開。我想說，好人兩個字是最能概括你們的全部。

也許扯的有點遠了，但歷經磨難最終過了四級后的我的心情是很激動的，所以就多說了點，老師們不要見怪。

出成績的當天，我匆匆洗完澡后，打開查分的網頁，然后下載了一張耶穌的畫像，并把它設置成我的桌面。最后呆呆地坐在電腦桌前，閉上雙眼，合上雙手，做起了長達一個小時的祈禱。雖然我不信基督教，但我腦中卻始終默念著神啊，拯救我吧，因為我的內心充滿了擔憂的急切的渴望。我把上帝作為了我當時心靈上唯一幫助。當其他宿舍傳來叫喊聲時，我知道能夠查分了。于是在網頁上輸入準考證號后，我又閉上了雙眼，又默念了一句神啊，拯救我吧。當睜開眼時，我立刻欣喜若狂了起來，因為上面顯示的是66.5分。據我同宿舍的哥們說，我當時的尖叫聲跟一個柔弱的女孩子突然見到一個可怕的毒蛇爬到腳下時沒有什么區(qū)別。

篇6

英語四級感謝信寫作講解：

1. 格式要正確。與其他應用文寫作一樣，書信體裁需要在正文的前面加上稱呼，在正文的末尾加上結束語，落款和署名。

2. 標點符號要正確。Dear+稱謂的后面一定要用逗號，不能用冒號。還要注意英語的句號是實心的，并且涉及到書名、電影名或者作品名的，要大些，英語中沒有書名號。

3. 考生需要根據題目要求完成寫作。在這一部分，考生需要注意字數的要求是120-180字，不能少些或者超出。另外，雖然題目中并未對落款人作過多要求，但是考生還是有必要把敏感的人名、地名和學校名去掉，以防作弊嫌疑。

4. 通過三個題目的要求，我們都要明確表明我們的感激之心，表述時要目標明確，語言貼切、充分，內容言之有物，句子流暢地道。

英語四級感謝信真題1：感謝朋友

For this part, you are allowed 30 minutes to write a letter to express your thanks to one of your friends who helped you most when you were in difficulty. You should write at least 120 words but no more than 180 words.

英語四級感謝信真題1范文：

Dear parents,

This letter is to tell you my true feelings from the bottom of my heart. Although we can keep in virtual touch every day, I still feel it not enough to let you know how much I love you and how much Ive appreciated what youve done for me.

In the past 20 years, you have done a lot for me. Firstly, thank you so much for bringing me up. I know how hard youve being working in the past. I can imagine how many difficulties and obstacles youve conquered. Second, I want to thank you for your good education on me. There is an old saying goes like this parents are the first teachers to their children. Both of you are the typical ones. The most important thing that I want to say thank you is for your great admiration on my own freedom. You told me to look over the horizons and to pursuit my own dreams without hesitation.

I really feel that my pen fails me when I am writing this thank you letter. The only thing I hope you can do for me is to take good care of yourselves and you will be always proud of me.

Yours beloved

Son

英語四級感謝信真題2范文：

Dear Mary,

I would like to take this opportunity to express my heartfelt gratitude to you for your help when I was in difficulty. You have been very kind and helpful since we knew each other.

Last week, I caught a bad cold and had to stay at home for a week. When I was worrying about the lessons, you came to my home after school and helped me with every subject. With your help, I didnt fall behind others.

Again, thanks so much for your enthusiastic help. Even though you are to about to go abroad for further education I know that I will always stay in touch with you. I wish you every success in the future and I hope we can exchange more viewpoints on study.

Please keep in touch, and drop in and visit us whenever you are in this part of the world.

Very sincerely

Peter

英語四級感謝信真題2：感謝老師

Directions: For this part,you are allowed 30 minutes to write a letter to express your thanks to your parents or any other family member upon making a memorable achievement. You should write st least 120 words but no more than 180 words.

英語四級感謝信真題3范文：

Dear sir,

I am writing to you to express my thanks for your help in learning English. You are one of the best teachers who I have ever met .There are many good points that I learn from you.

During these days in your class, I have acquired much knowledge from you and it really helps me a lot. Firstly, you let me know what the west thinking pattern is -straight thinking pattern. As an English learner, it is important for me to understand the difference between them. Whats more, Im glad to be your student, and I am very happy to learn the course under your guidance. English is an important tool, through which we can share our experience with the world. I treasure the chance of learning English, and I enjoy the happiness from your course.

The last not the least, please forgive those mistakes I have made which may upset you. What I have learned from you will help me pass the coming examinations and also be useful for my further education in abroad. It is not only a progress of learning, but also a cultivation of my ability.

May everything goes well around you.

Your student,

Li ling

篇7

新生兒腹瀉是由多種病原多種因素引起的，以大便次數增多和大便性狀改變?yōu)樘攸c的一組消化道綜合征【1】。主要是由于新生兒消化系統(tǒng)發(fā)育不成熟，生長發(fā)育快，機體防御功能差，腸道菌群失調等因素造成的【2】。因此，在積極治療疾病的同時，給予積極完善的護理干預措施可以促進患兒的康復。對我兒科2013年1月-2013年12月收治的新生兒腹瀉患兒給予護理干預措施，取得滿意效果，現將護理干預措施報道如下。

1 資料與方法

1.1 一般資料

選取2013年1月-2013年12月在我兒科治療的新生兒腹瀉患兒240例作為研究對象，隨機分成對照組和觀察組，對照組120例，其中男78例，女42例；年齡6d-24d，平均年齡14.1±0.6d；腹瀉次數5-14次，每次45-190ml。觀察組120例，其中男74例，女46例；年齡11d-23d，平均年齡15.3±0.6d；腹瀉次數4-15次，每次40-180ml。所有患兒入院后均經大便常規(guī)檢查顯示，白細胞（++-+++），脂肪球（+-++），均符合新生兒腹瀉的診斷標準【3】。所有患兒家屬均簽署知情同意書。兩組患兒在年齡、性別、腹瀉次數方面無統(tǒng)計學意義（P>0.05），具有可比性。

1.2護理方法

1.2.1 對照組給予常規(guī)護理措施。

1.2.2 觀察組給予護理干預措施。

1.2.2.1 嚴密觀察患兒病情變化

患兒入院后嚴密觀察患兒的體溫、呼吸、脈搏等生命體征，準確記錄患兒大便的次數、顏色、形狀等，有無低鉀、低鈣等電解質紊亂癥，有無脫水及其脫水的程度，對于脫水程度不重的患兒給予口服補液鹽，服用方法：體重（kg）*75ml=用量ml/d；對于脫水嚴重且伴有代謝性酸中毒的患兒給予靜脈補液，補液時準確計算補液總量補液成分和補液速度。

1.2.2.2 飲食護理

要根據患兒的腹瀉、嘔吐、食欲和消化情況，確定飲食的方法，對嘔吐、腹瀉嚴重患兒可暫時禁食6-8h，以利腸道休息，減少嘔吐及腹瀉次數，一般不禁水，行母乳喂養(yǎng)的新生兒應持續(xù)喂哺母乳；對于人工喂養(yǎng)的腹瀉較重的新生兒，要減少奶量并用水稀釋，可用1份牛乳加1/2份水，待腹瀉好轉后逐漸增加至全奶。當患兒腹瀉好轉時，可以按照從稀到稠、從軟到硬的規(guī)律逐漸過渡的原則，少量多餐。

1.2.2.3 健康教育

首先宣傳母乳喂養(yǎng)的優(yōu)點，避免在夏季斷乳；新生兒的奶瓶用前應煮沸消毒20分鐘，吃剩的奶液應倒掉；母親應保持乳房的清潔，勤換內衣，盡量減少感染的機會；對于母乳不足可采取混合喂養(yǎng)及人工喂養(yǎng)的辦法，但是要注意飲食調配，避免發(fā)生碳水化合物消化不良，影響寶寶生長發(fā)育；同時注意新生兒腹部的保暖，避免受涼。

1.3 觀察項目

對比分析兩組患兒的治療效果和患兒家屬滿意度。

1.4 療效評定標準

采用姚鳳一，陳凡【4】等評定標準，采用非常滿意（80-100分）、滿意（60-79分）和不滿意（

1.5 統(tǒng)計學方法

應用SPSS17.0對數據進行分析，計數資料采用χ 2檢驗，計量資料比較采用t檢驗，P

2 結果

2.1 兩組患者的治療效果比較

實施護理干預后，觀察組總有效率為94.2%，對照組總有效率為70.8%，觀察組的治療效果明顯優(yōu)于對照組，兩組比較差異有統(tǒng)計學意義（P

表1兩組患兒的臨床治療效果比較[n（%）]

組別 例數 顯效（例） 有效（例） 無效（例） 總有效率（%）

觀察組 120 91（75.8） 22（18.3） 7（5.8） 113（94.2）

對照組 120 46（38.3） 39（32.5） 35（29.2） 85（70.8）

X? 3.132 3.151 3.164 3.217

P值 P

2.2 兩組患兒家屬滿意度比較

實施護理干預后，觀察組的患兒家屬滿意度為98.3%，對照組的患兒家屬滿意度為74.2%，觀察組明顯優(yōu)于對照組，兩組比較差異有統(tǒng)計學意義（P

見表2

表2兩組患兒家屬滿意度比較[n（%）]

組別 例數 滿意（例） 基本滿意（例） 不滿意（例） 總滿意度（%）

觀察組 120 97（80.8） 21（17.5） 2（1.7） 118（98.3）

對照組 120 57（47.5） 32（26.7） 31（25.8） 89（74.2）

X? 3.242 3.272 3.261 3.286

P值

篇8

如何寫感謝信？

感謝信的寫作格式是書信體。寫作時應篇幅短，中文200字左右即可；對收信人為自己做的好事了然于胸，不要忘了什么；把對方給你帶來的好處都寫清楚，不要含糊其詞；表示感謝的話要合乎商家往來的習慣，語氣不應過于卑屈。謝意之外，如果允許別人什么應切實可行，能說到做到。

相關的感謝信樣本

·英語感謝信 ·國家助學金感謝信 ·寫給學校的感謝信

·見義勇為感謝信 ·拾金不昧感謝信范文 ·面試后的感謝信

感謝信范文

xxxxxxx有限公司于xx年x月x口在南京舉行隆重開業(yè)典禮，此間收到全國各地許多同行、用戶以及外國公司的賀電、賀函和賀禮。上級機關及全國各地單位的領導，世界各地的貴賓，國內最著名的xxx線路專家等親臨參加慶典，寄予我公司極大的希望，謹此一并致謝，并愿一知既往與各方加強聯系。進行更廣泛、更友好的合作。

xxxxxxx有限公司

董事長:xxx

篇9

無創(chuàng)機械通氣是急性左心衰患者的有效輔助治療方法之一，可明顯改善患者的呼吸狀況，保證有效通氣，可明顯緩解患者的急性左心衰狀況，改善心肌功能，進而明顯提高患者的生活質量，改善患者的預后[1-2]。為了探討護理干預在急性左心衰患者使用無創(chuàng)機械通氣治療中的影響，本院選取2011年11月～2013年11月診治的急性左心衰患者142例，均行無創(chuàng)機械通氣治療，根據護理方案分為兩組，行常規(guī)護理和護理干預，針對兩組患者的主訴恐懼情況、主訴配合情況、主訴并發(fā)癥情況進行對比分析，現報告如下。

1.資料與方法

1.1資料

本院2011年11月～2013年11月診治的急性左心衰患者142例，年齡為47～81歲，平均年齡為67.3±5.9歲，其中男性108例，女性34例。患者均符合急性左心衰的診斷標準，且經臨床表現和實驗室檢查確診，排除患有其他器質性病變、血液病、免疫性疾病的患者，均行無創(chuàng)機械通氣治療。根據護理方案分為兩組，常規(guī)護理患者71例為對照組，護理干預患者71例為觀察組，兩組患者的基礎資料（性別、年齡等）差異均無統(tǒng)計學意義（p>0.05），具有可比性。

1.2方法

觀察組患者實施護理干預：⑴基礎干預。護理人員采用和藹可親的語言和患者進行交流，建立良好的醫(yī)患關系，取得患者的信任，通過溝通與交流，幫助患者消除焦慮、抑郁、恐懼、害怕、緊張、擔心等不良心理因素，幫助患者建立配合治療的信心和決心，建立良好的干預基礎。⑵情緒干預。向患者講解疾病的相關知識和治療的有效方法，使患者了解到疾病治療的目的和意義，使其可以正視疾病的治療，在治療過程中，患者出現恐懼感時要給予及時的安慰和鼓勵，采用支持性語言和肢體語言穩(wěn)定患者的情緒，提高患者的耐受性，消除患者的不安狀況，減輕患者的恐懼病癥。⑶行為干預。指導患者在治療過程中采用端坐位，將頭部與肩頸處于同一水平位置，將頭后仰，確保呼吸道通暢，佩戴合適的面部口鼻罩，調節(jié)松緊度，設定吸氣相壓力由6cmH2O開始，設定呼氣相壓力由2cmH2O開始，增到患者的耐受，要確保患者的面部皮膚無受損，并在皮膚接觸部位放置紗布，減輕患者的壓迫感，在皮膚接觸部位涂抹凡士林，3h更換1次，每次20min，給予患者局部皮膚按摩等。⑷病情監(jiān)護。注意觀察患者的呼吸節(jié)律和心率狀況，確保主動呼吸和呼吸機同步，注意保持患者的呼吸道通暢，在加濕器內添加蒸餾水，將氣體濕化后進入氣道，指導患者掌握正確的呼吸方法。對照組患者實施常規(guī)護理?；颊咴谥委熯^程中，給予患者常規(guī)的基礎護理，保證患者的病房通風良好和環(huán)境的整潔衛(wèi)生，及時更換患者的床單被褥，只要患者實施正確的飲食和作息等。

1.3評定標準

主訴恐懼情況的評定標準：⑴輕度。患者不回避治療，無明顯的恐懼表現。⑵中度。患者有恐懼表現，曾試圖回避治療。⑶重度?；颊哂袕娏业目謶直憩F，盡力回避治療，在護士幫助下才能完成治療。

主訴配合情況的評定標準：⑴積極?；颊呖梢苑e極主動配合治療。⑵一般?；颊呖梢曰九浜现委?。⑶較差?；颊咝枰谧o士幫助下勉強完成治療。

主訴并發(fā)癥情況的評定標準：⑴輕度?；颊呙娌渴軌禾幤つw發(fā)紅和疼痛，停機5～10min后可恢復正常。⑵中度。患者主訴有腹脹感，可耐受，面部受壓處皮膚發(fā)紅和疼痛，停機5～10min不能恢復正常。⑶重度。患者主訴腹脹明顯，行胃腸減壓和肛管排氣后恢復，面部受壓處皮膚破損。

1.4統(tǒng)計學處理

數據資料均使用SPSS16.0統(tǒng)計學軟件進行處理和分析，計數資料均使用χ2檢驗，以p

2.結果

2.1兩組患者主訴恐懼情況比較

兩組患者主訴恐懼情況比較結果顯示（見表1），觀察組患者主訴恐懼情況明顯好于對照組，差異有統(tǒng)計學意義（p

表1兩組患者主訴恐懼情況比較（n，%）

2.2兩組患者主訴配合情況比較

兩組患者主訴配合情況比較結果顯示（見表2），觀察組患者主訴配合情況明顯好于對照組，差異有統(tǒng)計學意義（p

表2兩組患者主訴配合情況比較（n，%）

2.3兩組患者主訴并發(fā)癥情況比較

兩組患者主訴并發(fā)癥情況比較結果顯示（見表3），觀察組患者主訴并發(fā)癥情況明顯好于對照組，差異有統(tǒng)計學意義（p

表3兩組患者主訴并發(fā)癥情況比較（n，%）

3.討論

篇10

[關鍵詞] 西咪替??；干擾素；微量元素鋅；輪狀病毒感染性腹瀉

[中圖分類號] R725.1 [文獻標識碼] A [文章編號] 2095-0616（2017）08-40-03

[Abstract] Objective To curative effect analyze cimetidine and interferon combination of trace element zn in pediatric infectious diarrhea rotavirus. Methods 67 cases of children with infectious diarrhea rotavirus in our hospital from November 2015 to December 2016 were selected and divided into control group （implementation of cimetidine and interferon therapy） and treatment group （the implementation of cimetidine associated with interferon therapy trace element zine）. The curative effect of two groups were observed. Results The dehydration， stool and the recovery of body temperature and time of treatment group were significantly shorter than those of control group （P

[Key words] Cimetidine； Interferon； Trace element Zn； Infectious diarrhea rotavirus

臨床上，輪狀病毒感染性腹瀉在兒科中具有較高的發(fā)病率，引發(fā)本病的病原體主要為輪狀病毒，此病的主要臨床癥狀表現除了腹瀉之外同時普遍并發(fā)有脫水、發(fā)熱等癥狀，嚴重的甚至出現代謝紊亂以及酸中毒，通常好發(fā)于秋冬季節(jié)，若無法及時診斷并接受針對性治療，嚴重的甚至可直接引發(fā)死亡[1]?，F階段，臨床上對本病的發(fā)病機制尚無法明確，因而無統(tǒng)一的且具有明顯效果的治療標準[2]。為此，我院引入西咪替丁與干擾素聯合微量元素鋅治療，現將療效報道如下。

1 資料與方法

1.1 一般資料

67例均為我院自2015年11月～2016年12月期間收治的輪狀病毒感染性腹瀉患兒，納入標準：臨床癥狀均符合本病的癥狀表現，同時經病原學檢查確診。經醫(yī)院倫理委員會審批后，將67例患兒隨機分為治療組與對照組兩組，對照組32例，其中男17例，女15例；年齡0.7～4.5歲，平均年齡（1.6±0.8）歲。治療組35例，其中男19例，女16例；年齡0.8～4.4歲，平均年齡（1.6±0.7）歲。兩組患兒在基線資料方面對比差異無統(tǒng)計學意義（P>0.05），具有可比性。

1.2 方法

兩組均給予常規(guī)檢查，同時結合脫水的嚴重程度給予補液治療，給予發(fā)熱以及嘔吐者對癥治療，注意兩組均不能給予抗生素治療?；诖?，對照組采用西咪替丁注射液（湖南漢森制藥股份有限公司；H43021799）10～15mg/（kg?d）治療，給藥方式為靜脈滴注，同時增加重組人干擾素α1b [安徽安科生物工程（集團）股份有限公司；S20040010]治療，給藥方式為注射，劑量為100萬U/次，1次/d。在此基礎上，治療組聯合葡萄糖酸鋅口服液（湖北福人金身藥業(yè)有限公司；H20065022）治療，給藥方式為口服，每支的含鋅量為0.03g，1支/d，兩組的療程均為10d。

1.3 觀察指標及評定標準

記錄兩組大便及體溫恢復時間、脫水糾正時間。記錄兩組面色潮紅、煩躁以及腹瀉加重等不良反應情況。對兩組治療效果進行評估，若3d后，癥狀消失，同時糞便次數以及形狀均正常則評定為顯效；若3d后癥狀明顯緩解，同時糞便次數及形狀明顯好轉則評定為有效 ；若3d后癥狀未見任何緩解，同時糞便次數及形狀未見任何改善則評定為無效?？傆行?100%-無效率。

1.4 統(tǒng)計學分析

使用SPSS19.0統(tǒng)計學軟件處理數據，兩組計數資料對比行χ2檢驗，兩組計量資料對比行t檢驗，用P

2 結果

2.1 兩組治療基本情況比較

治療組脫水、大便以及體溫等的恢復時間均分別明顯短于對照組（P

2.2 兩組治療效果比較

治療組治療總有效率為97.14%，明顯高于對照組的71.88%（P

2.3 兩組不良反應比較

治療組不良反應發(fā)生率為2.86%，與對照組的不良反應發(fā)生率6.26%對比差異無統(tǒng)計學意義（P>0.05），詳見表3。

3 討論

臨床上，感染性腹瀉屬于兒科中常見的一種腸道感染性疾病，出現腹部疼痛以及糞便不成形等為本病的主要癥狀表現[3-4]。人體小腸內部的載膜絨毛上皮細胞中存在一種可以與輪狀病毒外殼中含有的VP4相互結合的病毒原體，因此小腸成為了輪狀病毒侵入的重要部位[5]。待病毒繼續(xù)侵入機體上皮細胞之后，便會誘發(fā)機體內的大量非結構蛋白糖基化，進而引發(fā)細胞膜發(fā)生紊亂現象，例如鈣離子通透性，一旦機體細胞內的鈣離子出現大量增多的現象，便會引發(fā)高鈣低氯癥狀，進一步可增加病毒非結構蛋白NSP3抑制蛋白正常合成的風險，進而將影響小腸上皮細胞的運行，嚴重的甚至可導致其脫落，極大的減少了雙糖轉化為單糖過程中所需的腸載膜上絨毛酶的數量，隨著時間的延長，雙糖大量堆積在腸道內，便極易增加腸腔內滲透壓，進而誘發(fā)腹瀉、嘔吐及脫水等癥狀，嚴重的可并發(fā)水電解質紊亂以及酸中毒等嚴重威脅患兒生命的癥狀[6-7]。

西咪替丁是一種H2受體拮抗劑，能夠顯著抑制因組胺或者胃泌素引發(fā)的胃酸分泌，進而避免受損腸黏膜長期處在酸性環(huán)境中而對其起到保護作用，并有利于為絨毛的修復創(chuàng)造良好條件[8-9]。此外，此種藥物還具有免疫調節(jié)作用，能夠通過提高患兒機體內的T淋巴細胞的轉化率而起到增強其免疫力的效果，進而能夠避免炎癥反應誘發(fā)的一系列繼發(fā)性損傷問題[10-11]。干擾素則具有免疫調節(jié)以及抗病毒效應等多種生理功能，在本病的治療過程中具有顯著的價值[12]。刷狀緣中大部分酶類均對鋅元素存在較強的依賴性，同時鋅離子能夠顯著的抑制小腸黏膜的增生，且能夠促進其完全角化，進而能夠對腸黏膜起到保護作用，此外，還可抑制胃腸激素分泌，增加腸內鈉氯離子的吸收能力，進而能夠對腸腔的滲透壓起到降低的效果[13]。除此之外，鋅離子還具有免疫調節(jié)以及抑菌等多種功效。特別值得關注的是，我院在采用西咪替丁與干擾素常規(guī)治療的基礎上增加微量元素鋅的一個理論基礎是此類型的患兒血清中鋅代謝有異常的現象[14-16]。

本研究中，治療組脫水、大便以及體溫等的的恢復時間均分別明顯短于對照組（P

綜上，將西咪替丁與干擾素聯合微量元素鋅應用于輪狀病毒感染性腹瀉患兒的治療中，可以快速消除患兒的癥狀，促進其康復，具有療效理想，安全性高的特點，值得臨床上推廣及應用。

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